I have a theory: that Douglas Adams' Hitchhiker's Guide to the Galaxy was close when wondering that, if the secret of the universe was ever found, it would be replaced by something even more improbable.
It happened, someone found it, or at least the secret of the bit over which humanity believes they have a loose measure of control. Why else would our world be changed daily beyond our understanding upon awakening‽
Douglas Adams:
"If you try and take a cat apart to see how it works, the first thing you have on your hands is a non-working cat."
Prompted by @der_jeff:
"Has the world come to an end yet?"